TITLE:
Hematological and Biochemical Profile of Sickle Cell Patients in Critical and Inter-Critical Periods in Brazzaville, Republic of Congo
AUTHORS:
Edwige Paola Louanga Nanitelamio, Serge Oscar Mokono, Chaldam Jespère Mbani, Olivia Galiba Atipo-Tsiba, Fabien Roch Niama, Etienne Mokondjimobe, Donatien Moukassa, Ange Antoine Abena, Alexis Elira Dokekias
KEYWORDS:
Sickle Cell Disease, Hematological Parameters, Biochemical Parameters, Critical and Inter-Critical Period Brazzaville
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.11 No.2,
June
23,
2021
ABSTRACT: Introduction: Sickle cell disease is a public health problem in
the Republic of Congo where the prevalence of sickle cell trait is estimated at
1.25%. The objective of this study is to describe the variations of
hematological and biochemical parameters of hemolysis in sickle cell patients
in critical and inter-critical periods. Methods: This is a descriptive
cross-sectional study including sickle cell patients followed regularly at the
National Reference Center for Sickle Cell Disease (CNRDr) from November 2019 to
March 2020. A sample of 167 patients (sickle cell subjects in crisis and in
steady state as well as control subjects) was randomly selected during the
study period. The blood count was performed using a Sysmex-XN 350 automated
system and the biochemical parameters were determined using the Cobas e 311
automated system. Statistical analysis was performed with SPSS version 22
software. Results: The study showed that the mean cholesterol level in
controls was 4.16 ± 0.77 ul compared with 9.64 ± 4.34 ul in sickle cell crisis
subjects. Hb and HCT levels were significantly higher in controls compared with
sickle cell subjects in crisis. During crisis, total bilirubin, direct
bilirubin, triglycerides, LDH, AST, and CRP were significantly elevated.
Hematological parameters such as Hb and HCT were elevated in controls, while
the mean WBC value and RET were higher in sickle cell patients in steady state.
The mean values of the biochemical parameters were higher in sickle cell
patients in steady state. Conclusion: Evaluation of the influence of
sickle cell trait on biochemical and hematological parameters showed
significant differences between sickle cell and control subjects.