TITLE:
Opportunistic Infections in Late Kidney Transplantation with Death Outcome: Case Report
AUTHORS:
Miriam Viviane Baron, Carina Marangoni, Michele Paula dos Santos, Célia Regina Martins Korzenieski, Vitória Pereira Itaquy, Tais Michele Werle, Gabriela Di Lorenzo Garcia Scherer, Joice Nedel Ott, Marcus Vinicius de Mello Pinto, Janine Koepp, Carolina Gonçalves Pinheiro, Nathália Ken Pereira Iketani, Cristine Brandenburg, Aline Ronis Sampaio, Alexandre Sancho, Danielle de Mello Florentino, Bartira Ercília Pinheiro da Costa
KEYWORDS:
Renal Transplantation, Infections, Opportunistic, Immunosuppressive Agent, Cytomegalovirus, Pneumocystis
JOURNAL NAME:
Open Journal of Nephrology,
Vol.11 No.2,
May
13,
2021
ABSTRACT: Cytomegalovirus (CMV) and Pneumocystis jirovecii fungus are the main opportunistic microorganisms that affect transplanted individuals. Immunosuppressive drugs administered to prevent organ rejection leave the immune system vulnerable to these infections. The present report is about a kidney transplanted patient using immunosuppressants who was diagnosed with cytomegalovirus and pneumocystosis requiring admission to the intensive care unit (ICU). Female patient, 57 years old, a kidney transplanted three years ago, with comorbidities, such as systemic arterial hypertension, hypertriglyceridemia and type 2 diabetes mellitus. She was admitted to the hospital in January 2020 with a history of diarrhea, cough, malaise and weight loss of seven kg in a month. She made continuous use of the immunosuppressants tacrolimus® and mycophenolate sodium (MFS). After five days of hospitalization, she was transferred to the ICU due to refractory diarrhea, worsening renal function and respiratory pattern, requiring mechanical ventilation. Chest tomography showed changes that led to the diagnostic hypothesis of CMV pneumonia or Pneumocystis jirovecii. Treatment with Ganciclovir® and Bactrim® was started. The bronchial lavage polymerase chain reaction test confirmed the infectious condition for CMV and Pneumocystis jirovecii. Despite the drug therapy instituted, there was no improvement in the infectious condition. The patient started to present a general and progressive worsening of the clinical picture with loss of renal graft function, respiratory failure, metabolic acidosis, hemodynamic instability and severe distributive shock, evolving to death. In the present report, it was observed that after late kidney transplantation the fragility of the immune system caused by the use of immunosuppressants contributed to the development of a severe infection with CMV and Pneumocystis jirovecii. Adjusting the doses of immunosuppressants to individual needs can be an important measure for maintaining the proper immune system and consequently avoiding late opportunistic infections and death outcomes.