TITLE:
Syntheses, Characterization, Antimicrobial Activity and Extraction Studies of Tetraaza Macrocyclic/Linear Schiff Bases Derived from Benzene-1,4-Dicarboxaldehyde and Their Coordination Compounds
AUTHORS:
Temitayo Aiyelabola, Johan Jordaan, Daniel Otto, Ezekiel Akinkunmi
KEYWORDS:
Component, Formatting, Style, Styling, Insert
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.3,
May
12,
2021
ABSTRACT: Non-template [2 + 2] condensation of benzene-1,4-dicarboxaldehyde
with two diamines: ethane-1,2-diamine and propane-1,2-diamine was carried out to give Ligands 1 and 2. Additionally,
template [1 + 2] condensation of benzene-1,4-dicarboxaldehyde
with ethane-1,2-diamine and propane-1,2-diamine were also carried out to
give Ligands 3 and 4. These were characterized using 1H
and 13C NMR, UV-Vis and infra-red spectroscopy and mass
spectrometry. Coordination compounds of each ligand were further synthesized
using Ni(II) and Cu(II) ions. They were characterized by Uv-vis, infrared spectroscopy, mass spectrometry,
magnetic susceptibility and energy dispersion X-ray spectroscopy EDX. The
ligands and complexes were further analyzed for their antimicrobial activities and extraction
efficiency. The results obtained suggested that tetraaza macrocyclic and linear
compounds were obtained for [2 + 2] and [1 + 2] condensation reactions respectively.
Coordination compounds of the macrocyclic ligand yielded octahedral geometry
for Ni(II) and Cu(II) complexes of Ligand 1 and square planar geometry
for Ni(II) and Cu(II) complexes of Ligand 2. On the other hand square
planar geometry was proposed for coordination compounds of Ligand 3 and 4 exception for the Ni(II) complex of Ligand 3. All ligands coordinated to the
metal ion in a tetradentate fashion. In some cases chelation enhanced the
antimicrobial activity of some of the ligands. The results further showed that
Ligands 1-4 effectively extracted cadmium(II). zinc(II) and
lead(II) ions in solution.