TITLE:
Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome)
AUTHORS:
Javier Ortiz Rodríguez-Parets, Luis Miguel Chinchilla Tábora, Enrique Montero Mateos, Elisa Muñoz Torres, María Dolores Ludeña de la Cruz
KEYWORDS:
Dysplastic Gangliocytoma, Immunohistochemistry, Cowden Syndrome
JOURNAL NAME:
Open Journal of Pathology,
Vol.11 No.2,
April
26,
2021
ABSTRACT:
Objective: To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. Material and Methods: Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. Results: A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. Conclusions: Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.