TITLE:
Synthesis and Characterization of Zinc Oxide and Zinc Oxide Doped with Chlorine Nanoparticles as Novel α-Amylase Inhibitors
AUTHORS:
A. Al-Arfaj Ahlam, N. Abd El-Rahman Soheir
KEYWORDS:
Zinc Oxide Nanoparticles, Zinc Oxide Nanoparticles Doped with Chlorine, Crystallinity, Anti-Diabetic Activity, α-Amylase Inhibitors
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.12 No.3,
March
29,
2021
ABSTRACT: In this study we used a chemical solution method from oxalic acid (OX. acid)
and zinc acetate (ZnAc) to prepare Zinc Oxide nanoparticles (ZnONPs) and Zinc
Oxide nanoparticles doped with Chlorine (Cl:ZnONPs). The characterizations
(FTIR, X-ray, SEM, TEM) of ZnONPs and Cl:ZnONPs were determined. Amylase
inhibitors of ZnONPs and Cl:ZnONPs also were determined. SEM indicated that the
ZnONPs and Cl:ZnONPs have an average particle size of 46.65 - 74.64 nm. TEM
images of the ZnONPs and Cl:ZnONPs showed the round shaped. Compounds b, d and e
exhibited significant inhibitory activity against amylase enzyme (from
69.21 ± 1.44 to 76.32 ± 0.78), respectively, and were comparable with that of acarbose (86.32 ±
0.63) at 1000 μg, thereby, projecting ZnONPs and Cl:ZnONPs as α-amylase inhibitors.