TITLE:
Free Radical Scavenging, Enzyme Inhibitory and Anti-Staphylococcus aureus Properties of the Fruiting Bodies of Ganoderma lucidum, Lingzhi Mushroom
AUTHORS:
Md. Moyan Uddin PK, Mohammad Sayful Islam, Shariful Haque, Lutfa Akther, Rumana Pervin
KEYWORDS:
Ganoderma lucidum, Mushroom, Antioxidant Activity, Enzyme Inhibitory Activity, Anti-Staphylococcus aureus Activities
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.12 No.3,
March
22,
2021
ABSTRACT: The current study evaluated the
antioxidant, α-amylase inhibitory and
anti-Staphylococcus aureus activities of the fruiting bodies
of Ganoderma lucidum. Methanolic extract of G. lucidum (MEGL) was investigated for
its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl
(DPPH) assay and EC50 value was determined. α-Amylase inhibitory and anti-S. aureus activities were carried out by
conventional methods. The mushroom extract showed maximum free radical
scavenging activity at a dose of 500 μg/mL with EC50 value of
22.1399 μg/mL. EC50 value for the inhibition of α-amylase activity was found 22.6011 μg/mL. G. lucidum extracts
exhibited a concentration-dependent Anti-S. aureus activity. The vast differences
of this inhibition between lower and higher doses were assessed significantly
(p G. lucidum has moderate
antioxidant, α-amylase inhibitory,
and anti-S. aureus activities. Thus this mushroom may be the alternative plant
source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.