TITLE:
In Vivo Evaluation of Anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on Mycobacterium ulcerans: Influence of Alkalinity on the Activity of Antibiotics Used in the Treatment of Buruli Ulcer
AUTHORS:
L. H. Nkasa, K. J. Kadinekene, O. Kiabanzawoko, B. Tchey, S. Kimbonza, M. O. Lunguya, S. S. Karhemere Bin, M. C. Mulenga, T. J. J. Muyembe, S. J. Kayembe, K. M. Taba
KEYWORDS:
Buruli Ulcer, Mycobacterium ulcerans, Mathesia, Ethanolamine, Rifampicin, Ethambutol, Isoniazid, Kibadi Solution
JOURNAL NAME:
Open Journal of Medical Microbiology,
Vol.11 No.1,
March
18,
2021
ABSTRACT: The present study reports the in vivo anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on Mycobacterium ulcerans. It also explores
the influence of ethanolamine (alkali agent) on the in vivo activity of some antibiotics (Isoniazid, Rifampicin,
Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments
were conducted on adult white Wistar rats of both sexes with the
weights comprising between 110 - 165 g. The result obtained have shown that the phytomedicine MATHESIA (pH 10) has a
good in vivo activity on M. ulcerans and the duration for wounds
healing and total cicatrization was 6 days; whereas this duration was 10, 12,
14, and 16 days respectively for Rifampicin (IV, pH 10), Kibadi’s solution
(X, pH 10), Ethambutol (VIII, pH 10) and Isoniazid (VI, pH 10). The result also
showed that the use of the ethanolamine as alkali compounded in the treatment
of wounds due to Buruli ulcer along with other antibiotics reduced considerably
the duration of complete healing comparatively to their solutions at pH bellow
or equal to 7.