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https://doi.org/10.1371/journal.pone.0215061

has been cited by the following article:

• TITLE: Glutathione Reductase, Liver Transaminases and Atypical Lymphocytes Count as Early Predictive Biomarkers in Diagnosis of Thrombocytopenia in Dengue Viral Infection

  AUTHORS: Samantha Bandara, Lal G. Chandrasena, Hemantha Peiris, Visula Abesuriya, Arjuna De Silva, Chandima De Mel, Sanjay De Mel, Suranjith L. Seneviratne

  KEYWORDS: Dengue, Liver Transaminases, Glutathione Reductase, Atypical Lymphocytes

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.9 No.1, January 28, 2021

  ABSTRACT: Objective: The aim of the study is to identify whether Atypical Lymphocyte (AL), liver transaminases, and Glutathione Reductase (GR) can be used as potential biomarkers in the assessment of severity and thrombocytopenia in dengue. Methods: A cross-sectional analytical study was carried out on diagnosed dengue patients admitted to Nawaloka Hospital, Sri Lanka. Blood samples were taken from patients (n = 50) on the day of admission, 3rd and 5th day from admission for analysis of GR, aspartate transaminase, alanine transaminase, platelets, white blood cells, and Atypical Lymphocytes (AL). Results: GR level of all three measured stages had a higher area under the curve (>88%), high sensitivity and specificity compared to liver transaminases. A significant regression model represents on admission GR and AL levels as predictive variables to platelet levels in day 03 from admission (Day 3 Platelet level = 127155.3 - 383 * GR - 0.431 * AL). Conclusion: Liver transaminases, GR, and AL% can be considered as a profile of predictive biomarkers in early diagnosis of severity of dengue infection. The degree of thrombocytopenia can be predicted using on admission GR and AL% level in acute dengue viral infection.