TITLE:
Correlation between a Change of Drug Resistance of Klebsiella pneumonia and Defined Daily Doses of Antimicrobial Agents from 2014 to 2018
AUTHORS:
Jiuli Hu, Xu Xiao, Chanchan Hu, Rui Wang, Yanwu Zhao, Xiaoqin Zhu
KEYWORDS:
Klebsiella pneumonia, Antibiotic Consumption, Resistance, Correlation Analysis, Defined Daily Doses
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.11,
November
12,
2020
ABSTRACT: Introduction: The prevalence of Klebsiella
pneumoniae has rapidly increased in recent years and the distribution
differed greatly by region, We aimed to study the relationship between
antibiotic resistance and K. pneumoniae, especially carbapenem-resistant Klebsiella pneumoniae (CRKP) in our tertiary hospitals from 2014 to
2018. Methodology:
The antibiotic consumption data of K. pneumoniae were expressed as the
defined daily dose (DDD) per 100 inpatient days (DDDs). K. pneumoniae which isolated from
clinical samples in hospital between January
2014 and December 2018 were retrospectively analyzed, and the correlation
between antibiotic resistance rate and antibiotic frequency was analyzed. Results: From 2014 to 2018, a total of 2295 strains of K. pneumoniae were isolated, with the detection rates of 8.2%, 9.2%, 11.9%, 13.4% and 14.0%.
There were 423 strains of CRKP, with the detection rates of 7.5%, 5.8%, 17.8% 24.2% and 25.2% respectively. K.
pneumoniae showed different degrees of resistance to antibiotics and
showed an increasing trend year by year to carbapenems. The resistance rate of
imipenem was 2.5%, 2.8%, 9.9%, 12.3%, 13.4%, and the resistance rate of meropenem was 2.0%, 3.0%, 8.8%, 12.6%, 12.7%, respectively. The
resistance rate of most other drugs decreased. The DDDs values of
cefoperazone/sulbactam, piperacillin-tazobactam and gentamicin showed a strong
positive correlation with K. pneumoniae drug resistance rate (r > 0.8, P 0.05). Conclusions: The detection
rate of K. pneumoniae and CRKP
increased year by year, which was closely related to the dose of antibiotics. Strengthening
the management of antimicrobial drugs and standardising the use of
antimicrobial prescriptions were of great significance for delaying the
emergence of drug-resistant bacteria.