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https://doi.org/10.1016/j.drugalcdep.2004.05.009

has been cited by the following article:

• TITLE: Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection

  AUTHORS: Kalpana J. Kallianpur, Rasmus Birn, Lishomwa C. Ndhlovu, Scott A. Souza, Brooks Mitchell, Robert Paul, Dominic C. Chow, Lindsay Kohorn, Cecilia M. Shikuma

  KEYWORDS: Resting-State Functional Connectivity, Occipital, Atrophy, Inflammation, Monocytes

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.10 No.8, August 21, 2020

  ABSTRACT: Background: Brain atrophy and cognitive deficits persist among individuals with suppressed HIV disease. The impact of cannabis use is unknown. Methods: HIV+ and HIV- participants underwent cross-sectional magnetic resonance imaging and neuropsychological testing. Lifetime frequency, duration (years), and recency of cannabis use were self-reported. Relationships of cannabis use to resting-state functional connectivity (RSFC) and to 9 regional brain volumes were assessed with corrections for multiple comparisons. Peripheral blood cytokines and monocyte subsets were measured in the HIV+ group and examined in relation to cannabis exposure. Results: We evaluated 52 HIV+ [50.8 ± 7.1 years old; 100% on antiretroviral therapy ≥ 3 months; 83% with plasma viral load 10 times/lifetime was linked to more somatic symptoms, better executive function, and lower CD14+CD16++ monocyte count. Conclusion: HIV+ individuals demonstrated opposing associations with cannabis. Recent use may weaken RSFC and prolonged consumption may exacerbate atrophy of the accumbens and other brain regions. More frequent or recent cannabis use may reduce the inflammation and CD14+CD16++ monocytes that facilitate HIV neuroinvasion. HIV-specific cannabis studies are necessary.