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has been cited by the following article:

• TITLE: Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

  AUTHORS: Chioma Don-Lawson, Daniel Okechukwu Nweneka, Reminus Okah, Kingsley J. Orie

  KEYWORDS: Furfural, 1, 1-bis(2-Carbamoylguanidino)furan-2-ylmethane, Bioactivity

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.11 No.6, June 11, 2020

  ABSTRACT: This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, 1H-NMR, 13C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on Escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.