TITLE:
LRP5 Affects Homeostasis of the Periodontal Complex
AUTHORS:
Joo-Hyung Kim, Ye-Hyun Kim, Won Hee Lim
KEYWORDS:
LRP5, Periodontal Ligament, Homeostasis
JOURNAL NAME:
Open Journal of Stomatology,
Vol.10 No.3,
March
17,
2020
ABSTRACT: Purpose: The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP5) in this process by removing LRP5, and observing the effects of LRP5 depletion on cells of the periodontal structures. Material and Methods: The function of this LRP5 was evaluated by conditional elimination of the LRP5 gene using an Osteocalcin Cre driver. The OCN-Cre; mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. Results: Elimination of LRP5 in the periodontal complex of OCN-Cre;mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament. Conclusion: Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP5 in homeostasis of the periodontal ligament.