Jayadev, C., Vinekar, A., Mangalesh, S., Kummelil, M.K., Kumar, A.K., Kemmanu, V., Sivakumar, M., Mahendradas, P., Avadhani, K., Bauer, N., Webers, C.A. and Shetty, B. (2016) Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and Its Correlation with Visual Acuity in Asian Indian Premature Infants in Their First Year of Life. Current Eye Research, 42, 789-795.
https://doi.org/10.1080/02713683.2016.1236964

has been cited by the following article:

• TITLE: Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?

  AUTHORS: Elçin Süren, Ersan Çetinkaya, Mehmet Fatih Küçük, Musatafa Kalaycı, Muhammet Kazim Erol

  KEYWORDS: Cystoid Macular Edema, Photoreceptor, Retinopathy of Prematurity, Vascular Endothelial Growth Factor

  JOURNAL NAME: Open Journal of Ophthalmology, Vol.10 No.1, December 24, 2019

  ABSTRACT: Purpose: To investigate the effects of intravitreal anti-vascular endothelial growth factor (VEGF) for treatment of type-1 or aggressive posterior retinopathy of prematurity (ROP) on photoreceptor maturation in preterm infants using spectral domain optical coherence tomography (SD-OCT). Methods: A study group of 36 patients with ROP treated with anti-VEGF therapy was compared to a control group of 80 patients with ROP. All patients had undergone SD-OCT imaging at least once between 40 and 44 weeks post-menstrual age (PMA). Two imaging specialists evaluated the images for ellipsoid zone (EZ) development, cystoid macular edema (CME), sub-retinal fluid (SRF) at the fovea, and cone outer segment tips (COST). The outer nuclear layer thickness and the distance from the EZ to the central fovea was measured. Results: EZ development was observed in 18 (50%) patients in the study group and 68 (85%) in the control group (p = 0.002). CME was observed in 17 (47.2%) patients in the study group and 17 (21.2%) in the control group. The distance between the EZ and central fovea was 868 ± 440 μm in the study group and 725 ± 380 μm in the control group (p = 0.02). COST was not observed in any patient. Regression analysis indicated that anti-VEGF treatment and CME affect EZ development. Conclusions: Early photoreceptor maturation is correlated with preterm birth week but not ROP stage. Anti-VEGF treatment delays photoreceptor maturation in preterm infants.