Delgado, A.V., Mcmanus, A.T. and Chambers, J.P. (2003) Production of Tumor Necrosis Factor-Alpha, Interleukin 1-Beta, Interleukin 2, and Interleukin 6 by Rat Leukocyte Subpopulations after Exposure to Substance P. Neuropeptides, 37, 355-361.
https://doi.org/10.1016/j.npep.2003.09.005

has been cited by the following article:

• TITLE: Anti-Inflammatory Activity of Geldanamycin and Its Derivatives in LPS-Induced RAW 264.7 Cells

  AUTHORS: Thongchai Taechowisan, Winyou Puckdee, Watcharee Waratchareeyakul, Waya S. Phutdhawong

  KEYWORDS: Anti-Inflammatory Activity, Geldanamycin Derivatives, Streptomyces zerumbet, RAW 264.7 Cells

  JOURNAL NAME: Advances in Microbiology, Vol.9 No.4, April 29, 2019

  ABSTRACT: Geldanamycin (1) had been isolated as a major compound from Streptomyces zerumbet W14; an endophyte of Zingiber zerumbet (L.) Smith. Two new geldanamycin derivatives; 17-(tryptamine)-17-demethoxygeldanamycin (2) and 17-(5’-methoxytryptamine)-17-demethoxygeldanamycin (3) were synthe- sized and their anti-inflammatory activity was evaluated in LPS-induced macrophage RAW 264.7 cells by investigating their effects on the inhibition of production of NO, PGE2, TNF-α, IL-1β, IL-6 and IL-10. The data obtained were consistent with the modulation of TNF-α, IL-1β, IL-6, IL-10 production by these derivatives at concentration of 1 to 5 μg/ml. A similar effect was also observed when LPS-induced NO release and PGE2 production were tested. The inhibitory effects were shown in concentration-dependent manners. From the obtained results, it was concluded that two new gelda- namycin derivatives possess anti-inflammatory activity on LPS-induced RAW 264.7 cells. They could be useful for the management of inflammatory diseases.