TITLE:
Association between Urinary Neurotransmitter Status and Scoliosis Progression: A Case-Controlled Series
AUTHORS:
Mark W. Morningstar, Clayton J. Stitzel, Brian Dovorany, Aatif Siddiqui
KEYWORDS:
Histamine, Neurotransmitters, Norepinephrine, Scoliosis, Serotonin
JOURNAL NAME:
Open Journal of Clinical Diagnostics,
Vol.8 No.3,
September
7,
2018
ABSTRACT: Previous investigations into the relationship
between neurotransmitter abnormalities and idiopathic scoliosis have been
mixed. The purpose of the present study was to evaluate the differences in a
urinary neurotransmitter profile across three different groups. These groups
included a progressive scoliosis group, a non-progressive scoliosis group, and
a non-scoliotic control group. When evaluating urinary neurotransmitter levels
across all groups, statistically significant differences were observed between
all three groups for multiple neurotransmitters. The differences seemed to
increase as the scoliosis increased in Cobb angle measurement. Further studies
should seek to distinguish a potential cause or effect relationship between
these neurotransmitter abnormalities and idiopathic scoliosis onset and/or
progression.