TITLE:
Influence of Dosimetric Considerations in Evaluating Second Cancer Risks in Prostate Cancer
AUTHORS:
Raghda A. Elgendy, Wahib M. Attia, Ehab M. Attalla, Mostafa A. lnaggar
KEYWORDS:
Prostate Cancer, Second Cancer Risks, 3DCRT, Rotational Arc and IMRT
JOURNAL NAME:
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology,
Vol.7 No.2,
May
28,
2018
ABSTRACT: Influence
of dosimetric considerations in evaluating second cancer risks in prostate
cancer. Material and methods: Fifteen patients in this study suffering from
early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional
conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc
therapy), and 3) intensity-modulated
radiation therapy (IMRT) plan. Estimate secondary metastasis risk models:
Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of
exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to
calculate risk models. Result: The second cancer risk models (ERR and EAR) for
organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC
and IMRT and there is no significant difference for ERR and EAR model for
developing second
cancer risk in 3D-CRT, ARC and IMRT.