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has been cited by the following article:

• TITLE: Aberrant Light-Induced Depression is Associated with Impaired Sensorimotor Gating in Mice

  AUTHORS: Toshiaki Haga, Junichi Toei, Kenichi Mitsui, Mareki Ohtsuji, Yo Kodera, Kenichi Osada, Hiroyuki Nishimura

  KEYWORDS: Depression, Sensorimotor Gating, C3H/HeJ, Prepulse Inhibition, Circadian Rhythm

  JOURNAL NAME: World Journal of Neuroscience, Vol.8 No.1, December 15, 2017

  ABSTRACT: Mice subjected to an irregular light-dark cycle are known to lose their capacity to synchronize their behavioral rhythm to environmental light, and to show endophenotypes related to depressive disorders. Here we observed that a susceptible strain of mice (C3H/HeJ) subjected to an irregular 3.5 hr:3.5 hr light-dark cycle showed an enhanced acoustic startle reflex and deficits in prepulse inhibition. As impaired sensorimotor gating is associated with the onset of a variety of mental disorders such as schizophrenia and major depressive disorder, irregular environmental light without circadian photo-entrainment may cause stress that has the potential to be involved in humans’ susceptibility to neuropsychiatric abnormalities.