TITLE:
Inorganic Pyrophosphatases: Study of Interest
AUTHORS:
Mar Papa Daouda, El Khalfi Bouchra, Perez-Castiñeira Jose Roman, Serrano Delgado Aurelio, Soukri Abdelaziz
KEYWORDS:
Pyrophosphatases, Structure, Catalytic Activity, Phylogeny, Pathology
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.8 No.10,
October
31,
2017
ABSTRACT: Inorganic
pyrophosphatases are enzymes that catalyze the hydrolysis of inorganic
pyrophosphate to orthophosphate. These enzymes are divided into two groups: the
soluble pyrophosphatases and the membrane pyrophosphatases. They vary in
structure and each has a determined catalysis mechanism. Soluble
pyrophosphatases are ubiquitous enzymes and play a key role in regulating the rate of pyrophosphate and balance in this sense, the biosynthetic
reactions. Membrane pyrophosphatases are ion pumps, producing a proton or
sodium gradient, and provide critical energy reserves to organisms, especially
during stress conditions. Several studies have shown that these enzymes are
involved in numerous disorders (diseases, fault cell growth···). However they
are potential targets for the development of agents against parasites. This
article consists of a description of the different types, structures, catalytic
properties of inorganic pyrophosphatases and their involvement in cellular
metabolism.