Espinoza, J., Chaiworapongsa, T., Romero, R., Edwin, S., Rathnasabapathy, C., Gomez, R., Bujold, E., Camacho, N., Kim, Y., Hassan, S., Blackwell, S., Whitty, J., Berman, S., Redman, M., Yoon, B. and Sorokin, Y. (2003) Antimicrobial Peptides in Amniotic Fluid: Defensins, Calprotectin and Bacterial/Permeability-Increasing Protein in Patients with Microbial Invasion of the Amniotic Cavity, Intra-Amniotic Inflammation, Preterm Labor and Premature Rupture of Membranes. The Journal of Maternal-Fetal & Neonatal Medicine, 13, 2-21.
https://doi.org/10.1080/jmf.13.1.2.21

has been cited by the following article:

• TITLE: Human Beta Defensins 1, 2 and 3 Produced by Amniochorion Membranes Is Similar in Term and Preterm Delivery

  AUTHORS: Nathália Mayumi Noda-Nicolau, Jossimara Polettini, Camila Marconi, José Carlos Peraçoli, Hélio Amante Miot, Márcia Guimarães da Silva

  KEYWORDS: Preterm Birth, Amniochorion Membranes, Human Beta Defensins

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.7 No.8, August 2, 2017

  ABSTRACT: Amniochorion membranes were collected from 25 pregnant women at preterm labor, in the presence or not of Preterm Premature Rupture of Membranes (PPROM) and 27 pregnant women at term in the presence at labor, in order to quantify the expression and to evaluate the immunoreactivity of human beta defensins (HBD)1, HBD2, HBD3 and HBD4 in amniochorion membranes from pregnancies complicated by spontaneous prematurity. The HBDs were evaluated by immunohistochemistry, real time quantitative PCR and ELISA. Statistical analyses were performed using Chi-squared and Mann Whitney tests. There was no significant difference in HBDs expression between study and control groups: HBD1 (Md = 0.62 (0.0 - 105.0) vs Md = 0.80 (0.02 - 25.0); p = 0.85), HBD2 (Md = 0.17 (0.0 - 5.2) vs Md = 0.0 (0.0 - 43.2); p = 0.16), HBD3 (Md = 0.11 (0.0 - 140.5) vs Md = 0.06 (0.0 - 972.1); p = 0.91). Also, HBD1, HBD2 and HBD3 protein expression was not significant different between the groups: HBD1 (1.32 pg/mL (0.0 - 1.85) vs 1.08 pg/mL (0.04 - 2.22); p = 0.67), HBD2 (0.00 pg/mL (0.0 - 1.74) vs 0.02 pg/mL (0.0 - 1.24); p = 0.69), HBD3 (0.04 pg/mL (0.0 - 1.05) vs 0.09 pg/mL (0.0 - 1.05); p = 0.63). The immunoreactivity of HBD1, HBD2 and HBD3 was observed in amnion, chorion and decidua cells from preterm and term pregnancies. Amniochorion membranes are sources of HBD1, HBD2 and HBD3 and their expressions are similar in term and preterm pregnancies.