TITLE:
Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice
AUTHORS:
Mohammad S. AL-Harbi, Sayed A. M. Amer
KEYWORDS:
SeNPs, Mice, APAP, Hepatotoxicity, Antioxidant
JOURNAL NAME:
Natural Science,
Vol.9 No.7,
July
20,
2017
ABSTRACT: Selenium nanoparticles (SeNPs) have been widely used as
anti-inflammatory and anti-toxic agent. The present study used Bacillus
tequilensis for biosynthesizing SeNPs from sodium selenite (Na2SeO3)
and investigated its ameliorative effects on acetaminophen (APAP)
hepatotoxicity in male mice. The results indicated that Alanine transaminase
(ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP)
significantly elevated in mice treated with APAP, while other liver markers
(total proteins and albumin) did not change. SeNPs either alone or in
combination with APAP showed ameliorative effects on liver enzymes to some
extents where their activities decreased to be insignificant with those of
normal group. A slight variation was shown in total antioxidant capacity (TAC).
Histopathologically, the hepatocytes of the mice treated with APAP showed
cloudy swelling and vacuolar degeneration, while those treated with SeNPs or
both SeNPs and APAP appeared more or less histologically normal. In conclusion,
SeNPs can be used to improve or replace today’s therapies of APAP
hepatotoxicity.