TITLE:
World’s First Myoblast Treatment of Human Cancer Found Safe and Efficacious
AUTHORS:
Peter K. Law, Shi Jun Song, Ping Lu, Yong Gao, Mingzhang Ao, Hongdan Zhao, Liyun Bai, Kang Guo, Danlin M. Law
KEYWORDS:
Human Cancer Treatment, Tumor Shrinkage, Cancer Apoptosis, Metastasis Inhibition, Cancer Clinical Trial, TNF-α, Myoblasts, Myotubes, Nude Mice, Cell Therapy
JOURNAL NAME:
Open Journal of Regenerative Medicine,
Vol.6 No.1,
March
31,
2017
ABSTRACT: Evolution of placental mammals over the past 160 million years witnesses the relative sparing of muscles from cancer attacks. In 1) nude mice with human gastrointestinal or lung tumors, and 2) human subjects with liver, lung or gastrointestinal tumors, intra-tumor implantation of allogeneic human myoblasts induced cancer apoptosis, inhibiting metastasis and tumor growth. We postulate four mechanisms of cancer apoptosis: a) myoblasts releasing tumor necrosis factor-α (TNF-α); b) deprivation of nutrients and oxygen; c) local inflammatory and immunologic attacks; and d) prevention from metastasis. These basic and clinical studies demonstrated preliminary safety and efficacy of intra-tumor myoblast implantation in the development of prevention and treatment for cancer, now the number one disease killer of mankind.