TITLE:
Sleep Disturbance in Parkinson’s Disease Varies with Age of Onset and Family History
AUTHORS:
Divya Madhusudhan, Daniella Sisniega, Andrew Ferree, Janice Weinberg, Marie Saint-Hilaire, Samuel Ellias, Anna DePold Hohler
KEYWORDS:
Parkinson’s Disease (PD), Sleep Disorders, Rapid Eye Movement Behavior Disorder (RBD), Age, Non-Motor Symptoms, Familial PD
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.5 No.4,
November
30,
2016
ABSTRACT: Introduction: Parkinson’s disease (PD) is a progressive neurodegenerative disease more common in those over the age of 60. PD is classically characterized by motor features, although patients may also experience non-motor symptoms. Sleep disturbances, such as rapid eye movement (REM) behavior disorder (RBD), are common in patients with PD and may precede onset of PD. Methods: Data was collected on patients with PD (358 subjects)in a movement disorders clinic at a safety net hospital. In this retrospective database analysis, the association of PD complications with age of onset was evaluated using chi-square tests and logistic regression. Results: Of the PD complications analyzed, there was a significant difference in sleep disturbances by age. Among the 358 PD patients, 120 individuals (33.5%) had information regarding the presence or absence of sleep disturbances. There was a significant difference between the early (onset