Bokemeyer, C., Kohne, C. and Rougier, P. (2010) Cetuximab with Chemotherapy as First-Line Treatment for Metastatic Colorectal Cancer: Analysis of the CRYSTAL and OPUS Studies according to KRAS and BRAF Mutation Status. Journal of Clinical Oncology, 28, 15s.

has been cited by the following article:

• TITLE: Excision Repair Cross-Complementation Group 1 (ERCC1): A Prognostic and Predictive Biomarker in Patients with Colorectal Cancer Receiving Adjuvant Oxaliplatin Based Chemotherapy

  AUTHORS: Adel Gabr, T. M. Elsaba, Khalid Razek, Shaima Tamam, Haisam Atta

  KEYWORDS: ERCC1, CRC, Oxaliplatin, IH

  JOURNAL NAME: Journal of Cancer Therapy, Vol.7 No.9, September 1, 2016

  ABSTRACT: Background: Colorectal cancer (CRC) ranks as the third most common cancer and the third most killing cancer worldwide [1]. The addition of oxaliplatin to fluorouracil (FOLFOX) or capecitabine (CAPOX) has become a fundamental component of chemotherapeutic regimens and chemoradiation in adjuvant treatment of CRC cancer. Excision repair cross-complementation group 1 (ERCC1) encodes an enzyme that is essential for the efficient repair of DNA damage induced by platinum compounds including Oxaliplatin. Purpose: This study aims to investigate the role of ERCC1 as a predictive and prognostic marker in colorectal patients receiving oxaliplatin based chemotherapy and chemoradiation. Patients and Methods: 100 annotated stage III CRC patients were prepared as immunohistochemical (IHC) analysis of ERCC1 protein expression. All of the patients received oxaliplatin based chemotherapy. Results: Analysis of data showed that high ERCC1 expression was significantly associated with early treatment failure and disease free survival among patient with stage III CRC. Conclusion: High ERCC1 expression was an independent predictor factor of early treatment failure (P = 0.004).