TITLE:
A Nonglycosylated 27 KDa Molecule as Common Antigen between Human Breast Cancer and Echinococcus granulosus Hydatid Cyst Wall
AUTHORS:
Seyedeh Maryam Sharafi, Raheleh Rafiei, Raheleh Rafiei, Mahboubeh Hadipour, Hedayat Shirzad, Hossein Khanahmad, Hossein Yousofi Darani
KEYWORDS:
Breast Cancer, Cross Reaction, Hydatid Cyst
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.5 No.2,
April
19,
2016
ABSTRACT: Background: Hydatid cyst, which has anti-cancer activities, is outwardly covered
with the cyst wall. It is in close contact with the host tissues and its
molecules presented to the immune system. In this work immunological reaction
of the sera of breast cancer patients with the hydatid cyst wall antigens has
been investigated. Method: For this purpose, sera of patients with breast
cancer, hydatid cyst and normal human sera were collected and their reaction
with hydatid cyst wall antigens was tested using western immunoblotting
technique. Results: All sera of patients with breast cancer, hydatid cyst and
also human normal sera reacted with a band in western immunoblotting. However,
sera of patients with breast cancer showed reaction with a 27 KDa band. Results
of this work also revealed that this band was not glycosylated and may express
only in some stages of breast cancer development. Conclusion: Sera of patients
with breast cancer cross reacted with a nonglycosylated antigen of hydatid cyst
wall. However, more work is recommended to find if this band involves in
anticancer activity of the hydatid cyst.