TITLE:
Increased Spot Urinary Protein-to-Creatinine Ratio Can Be a Useful Predictor of Preeclampsia
AUTHORS:
Mai Nishimura, Ayaka Nakashima, Takuya Kushimoto, Mayako Goto, Susumu Yoshida, Osamu Sato, Kayoko Shikado, Kazuhide Ogita
KEYWORDS:
Preeclampsia, Eclampsia, Protein-to-Creatinine Ratio, Pregnancy Induced Hypertension, Proteinuria
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.14,
December
1,
2015
ABSTRACT: Objectives: Preeclampsia is a major cause of maternal and perinatal
morbidity and mortality. Early diagnosis of preeclampsia is important to help
patients with preeclampsia. However, 24-hour urine collection is the gold
standard diagnostic method at present. Recently, the spot urinary protein-to-creatinine
ratio (P/C ratio) has been used to detect suspected preeclampsia, because it
can be used to estimate the amount of 24-hour urinary protein. The aim of this
study is to investigate whether an increase in P/C ratio precedes emergence of
hypertension among inpatients with preeclampsia. Method: The P/C ratio in
normotensive (systolic blood pressure 2 = 0.9913).
Twenty-one women were diagnosed with preeclampsia. In 14 patients with
preeclampsia, the timing of the increase in P/C ratio to higher than the
regression line preceded the emergence of hypertension. Six patients had no
data on P/C ratio, and 1 patient had hypertension before the increase in P/C
ratio. Conclusions: An increase in P/C ratio to higher than the 95th percentile
value can be a useful predictor of preeclampsia.