TITLE:
Antimicrobial Susceptibility and Sub-MIC Biofilm Formation of Moraxella catarrhalis Clinical Isolates under Anaerobic Conditions
AUTHORS:
Balbina J. Plotkin, Thomas Hatakeyama, Zheng Ma
KEYWORDS:
Anaerobic, Nitrate, Otitis Media, Sinusitis, Pneumonia, Biofilm, Sub-MIC, Anaerobic Respiration, Moraxella catarrhalis
JOURNAL NAME:
Advances in Microbiology,
Vol.5 No.4,
April
9,
2015
ABSTRACT: A medium
was developed to support the anaerobic growth and antimicrobial susceptibility
testing of clinical Moraxella catarrhalis isolates. The MICs of clinical Moraxella
catarrhalis isolates under anaerobic conditions were, in general, decreased
as compared to atmospheric or capnophilic conditions, while the MBCs for all
conditions were within a 2 fold concentration dilution. Biofilm formation was
affected by the presence of sub-MIC concentrations of azithromycin and the
tested quinolones with the exception of levofloxacin.