Mandala, S.M., Thornton, R.A., Milligan, J., Rosenbach, M., Garcia-Calvo, M., Bull, H.G., Harris, G., Flattery, A.M., Gill, C.G., Bartizal, K., Dreikon, S. and Kurtz, M.B. (1998) Rustmicin, a potent antifungal agent inhibits sphingolipid synthesis at inositol phosphoceramide synthase. Journal of Biological Chemistry, 273, 14942-14949. doi:10.1074/jbc.273.24.14942

has been cited by the following article:

• TITLE: Anti-yeast activities of Origanum oil against human pathogenic yeasts

  AUTHORS: Amber Adams, Satyanshu Kumar, John Clauson, Shivendra Sahi

  KEYWORDS: Origanum Vulgare; Candida Albicans; Cryptococcus Neoformans; Rhodotorula Rubrum; Cryptococcus Albidus

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.2, April 8, 2011

  ABSTRACT: Outbreak of autoimmune diseases by pathogenic yeasts has led to a serious medical threat. As these organisms evolve resistance to existing antifungal drugs, the concern could be further compounded. The realm of plant derived products offers a wide spectrum of potentially valuable alternatives to the existing synthetic fungicides. Essential oils from sev-eral medicinal plants have been shown to exhibit pharmacological attributes. In the present study, anti-yeast properties of Oregano essential oil (OEO) were examined in vitro against four human patho-genic yeasts i.e., Candida albicans, Cryptococcus al-bidus, Cryptococcus neoformans and Rhodotorula ru-brum. OEO concentration of 200 μg/mL was found to be growth inhibitory against all four yeasts examined, thereby showing its potential to function as a natural anti-yeast agent.