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has been cited by the following article:

• TITLE: 11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography

  AUTHORS: Miki Goto, Hiroshi Mizuma, Yasuhiro Wada, Masaaki Suzuki, Yasuyoshi Watanabe, Hirotaka Onoe, Hisashi Doi

  KEYWORDS: PET, Capsaicin, 11C-Labeling, TRPV1, Blood-Brain Barrier

  JOURNAL NAME: Food and Nutrition Sciences, Vol.6 No.2, February 4, 2015

  ABSTRACT: Synthesis of 11C-labeled capsaicin ([11C]-2) was accomplished by O-[11C]methylation with [11C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [11C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [11C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1.