Article citationsMore>>
Hagen, M.K., Lehenbauer-Lüdke, A.R., Paludo, A.C., Schenkel, P., Gon?alves, L., Fernandes, T.G., Caron, R., Llesuy, S., Mill, J.G. and Belló-Klein, A. (2009) Diet with Isolated Soy Protein Reduces Oxidative Stress and Preserves Ventricular Function in Rats with Myocardial Infarction. Nutrition Metabolism and Cardiovascular Disease, 19, 91-97.
http://dx.doi.org/10.1016/j.numecd.2008.03.001
has been cited by the following article:
-
TITLE:
Isolated Soy Protein-Based Diet Ameliorates Glycemia and Antioxidants Enzyme Activities in Streptozotocin-Induced Diabetes
AUTHORS:
Roberta Hack Mendes, Martine Kienzle Hagen, Jaqueline Barp, Erna Vogt de Jong, Júlia Dubois Moreira, Álvaro Reischak-Oliveira, Maria Cláudia Irigoyen, Adriane Belló-Klein
KEYWORDS:
Isolated Soy Protein, Diabetes, Oxidative Stress
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.5 No.21,
November
20,
2014
ABSTRACT: The objective of this study was to evaluate the changes induced by isolated soy protein (ISP)-based diet on glycemia and oxidative stress biomarkers in diabetic rats. Fifteen male Wistar rats (35 ± 4 g, aged 21 days) were assigned to three groups: Casein (C group), which received casein-based diet during experimental protocol; Diabetic treated with Casein (D + C group) that received casein-based diet before and after diabetes induction; Diabetic treated with ISP (D + S group) that received casein-based diet before diabetes induction and after received ISP-based diet for the experimental protocol. Diabetes was induced by a single dose of streptozotocin (50 mg/kg body weight i.v.). After three weeks of dietary treatment, total nitrates, lipid peroxidation, antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) were measured in heart homogenates. ISP-based diet promoted an improvement in the glycemic levels of diabetic rats compared with casein-based diet (362 ± 25 vs 461 ± 30 mg/dL). CAT activity demonstrated a significant decrease in D + C and D + S groups. D + S group presented a significant increase in SOD and GST activities. Lipid peroxidation was not different among experimental groups. The overall results suggested the potential benefits of ISP-based diet consumption to improve the life quality of diabetic patients.