TITLE:
Can Ophthalmoscope Predict Silent Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus?
AUTHORS:
Naglaa Abdul-Maboud Soliman, Wafaa Mostafa Abd-El Gawad
KEYWORDS:
Type 2 Diabetes Mellitus, Coronary Artery Disease, Diabetic Retinopathy, Tc99 Scan
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.5,
November
3,
2014
ABSTRACT: Background & Aim:
Diabetic retinopathy (DR) and Coronary Artery Disease (CAD) share similar
pathophysiological background of vascular damage. So we aimed to study the
relationship between DR and silent CAD in patients with type 2 diabetes
mellitus (T2DM). Subject & Methods: A cross sectional study was performed
on 40 patients with T2DM from diabetic outpatient clinic in Ain Shams University
Hospitals, Cairo, Egypt from June 2012 to December 2012. All patients were
subjected to data collection, laboratory analysis and imaging studies. Patients
with known CAD, abnormal resting or stress ECG, abnormal ejection fraction or
segmental wall motion abnormalities, smoking history, hypertension, or abnormal
lipid profile were excluded. Results: Mean age is 62.35 ± 1.38 years, 75% (n = 30)
were females, 75% (n = 30) had DR, and 77.50% (n = 31) had positive Tc99 scan. There is a significant positive association between Tc99 scan
and DR (p value = 0.029) as 86.7% of patients with DR had positive Tc99 scan. Resting and stress perfusion TC99 scan were significantly worse (91.77% vs 100%; 86.48% vs 96.27%, p value = 0.008,
0.005 respectively) and microalbuminuria were significantly higher (207 ±
29.65 vs 36 ± 10.66 mg/dl, p value =99 scan is recommended in patients with DR even if asymptomatic. More
multi-centric prospective studies are needed to elucidate the effect of the
degree of DR on CAD risk.