Article citationsMore>>
Mehta, H.H., Gao, Q., Galet, C., Paharkova, V., Wan, J., Said, J., Sohn, J.J., Lawson, G., Cohen, P., Cobb, L.J. and Lee, K.W. (2011) IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer. Cancer Research, 71, 5154-5163.
http://dx.doi.org/10.1158/0008-5472.CAN-10-4513
has been cited by the following article:
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TITLE:
Activation of Various Downstream Signaling Molecules by IGFBP-3
AUTHORS:
Hanief Mohammad Shahjee, Nisan Bhattacharyya
KEYWORDS:
Apoptosis, IGFBP-3, Stat-1, IGF-I, TGF-β
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.9,
August
7,
2014
ABSTRACT:
Insulin-like growth factor
binding protein-3 (IGFBP-3), a secretory protein, is the most abundant IGF
binding protein present in human serum among all IGF binding proteins. IGFBP-3
shows decreased level of expression in cancerous cells but has been known to be
present in significant amounts in normal or non-cancerous cells. IGFBP-3 can
induce apoptosis in prostate cancer cells either in an IGF-dependent manner or
independently of IGF binding. Although putative cell death specific
Insulin-like growth factor binding protein-3 (IGFBP-3R) receptor(s) has
recently been identified by which IGFBP-3 may induce its anti-tumor effects,
IGFBP-3 has also been known to activate various downstream intracellular
signaling molecules via a different mechanistic pathway. Stat-1 has been known
to be one of the candidate molecules activated by IGFBP-3. IGFBP-3 can also
inhibit Akt/IGF-1 survival pathway in MCF-7 breast cancer cells which
ultimately leads to the induction of apoptosis in these cells. All these
studies clearly demonstrate that IGFBP-3 regulates cell proliferation and
promotes its pro-apoptotic effects in cancer cells in two different pathways:
1) sequester IGF-I to bind to IGF-I receptor to inhibit cell proliferation and
induce apoptosis, 2) independent of IGF-I pathway, IGFBP-3 binds to some
putative receptor and activate various downstream pro-apoptotic molecules
involved in cell death.
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