TITLE:
Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum
AUTHORS:
Hyun Sik Park, In Youb Chang, Han Yong Kim, Sang Pil Yoon
KEYWORDS:
Ephexin-1; Cerebellum; Purkinje Cells; Development; Dog
JOURNAL NAME:
Neuroscience and Medicine,
Vol.5 No.1,
March
6,
2014
ABSTRACT:
Ephexin-1 functions as guanine nucleotide
exchange factors for the Rho-type GTPases which have important roles in
neuronal development including axon guidance, migration, morphogenesis, and
plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we
investigated the immunolocalization of ephexin-1 in the developing canine
cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and
ephexin-1 immunoreactivities gradually increased in developing canine
cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1
immunolocalization was observed in the Purkinje cells which aligned a single
layer during cerebellar development. These results suggest that ephexin-1 might
play an important role in the development of the Purkinje cells during the
first two postnatal weeks based on its immunolocalization in the present study.