TITLE:
The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects
AUTHORS:
Maxim Yu. Sinitsky
KEYWORDS:
Micronucleus Assay; Micronuclei; CBMN; DNA Damage; Radon; Uranium; Coal; Miners
JOURNAL NAME:
Open Journal of Genetics,
Vol.4 No.1,
March
5,
2014
ABSTRACT:
This paper discusses the problem of assessing the
negative after-effects of low doses of ionising radiation exposure in humans.
Radon and its decay daughter products are the most widespread source of such
irradiation. Miners (in both uranium and non-uranium mines) as well as
laypeople in domestic life may be exposed to radon, making the problem of
assessing the cytogenetic effects of exposure extremely crucial. One of the
more promising test systems to assess the effect of radon is the
cytokinesis-block micronucleus assay (CBMN) on peripheral blood lymphocytes,
which has a number of advantages over other cytogenetic techniques. Recent
progress and future prospects of this cytogenetic method are discussed here.