Article citationsMore>>
K. W. Haug, M. Warnstedt, Alekov, T. Sander, A. Ramirez, B. Poser, S. Maljevic, S. Hebeisen, C. Kubisch, J. Rebstock, S. Horvath, K. Hallmann, J. S. Dullinger, B. Rau, F. Haverkamp, S. Beyenburg, H. Schulz, D. Janz, B. Geise, G. Muller-Newen, P. Propping, C. E. Elger, C. Fahlke, H. Lerche and A. Heils, “Mutations in Clcn2 Encoding a Voltage-Gated Chloride Channel are Associated with Idiopathic Generalized Epilepsies,” Nature Genetics, Vol. 33, 2003.
has been cited by the following article:
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TITLE:
An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
AUTHORS:
Leonard A. Jason, Matthew Sorenson, Nicole Porter, Natalie Belkairous
KEYWORDS:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Kindling, Limbic-hypothalamic-pituitary Cxis
JOURNAL NAME:
Neuroscience and Medicine,
Vol.2 No.1,
March
17,
2011
ABSTRACT: Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus re-sulting in hypersensitivity and spontaneous seizure-like activity. Among patients with ME/CFS, chronically repeated low-intensity stimulation due to an infectious illness might cause kindling of the limbic-hypothalamic-pituitary axis. Kindling might also occur by high-intensity stimulation (e.g., brain trauma) of the limbic-hypothalamic-pituitary axis. Once this system is charged or kindled, it can sustain a high level of arousal with little or no external stimulus and eventually this could lead to hypocortisolism. Seizure activity may spread to adjacent structures of the limbic-hypothalamic-pituitary axis in the brain, which might be responsible for the varied symptoms that occur among patients with ME/CFS. In addition, kindling may also be responsible for high levels of oxidative stress, which has been found in patients with ME/CFS.
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