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Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T. (2000) Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell, 102, 553-563.
http://dx.doi.org/10.1016/S0092-8674(00)00078-7
has been cited by the following article:
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TITLE:
“Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells
AUTHORS:
Gao-De Li
KEYWORDS:
Natural Site-Directed Mutagenesis, Genetic Alteration, Mutation, CAGFs, DNA to DNA Transcription, Drug Resistance, Evolution of Eukaryotes, Antibody Diversity, Somatic Hypermutation
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.4,
April
18,
2016
ABSTRACT:
Site-directed mutagenesis refers to a man-made molecular biology method that
is used to make genetic alterations in the DNA sequence of a gene of interest. But
based on our recently published experimental findings, we propose that “natural
site-directed mutagenesis” might exist in eukaryotic cells, which is triggered by
harmful agents and co-directed by special transcription hotspots and mutation-contained
intranuclear primers.