Article citationsMore>>
Simon, N.W., Montgomery, K.S., Beas, B.S., Mitchell, M.R., LaSarge, C.L., Mendez, I.A., Banuelos, C., Vokes, C.M., Taylor, A.B., Haberman, R.P., Bizon, J.L. and Setlow, B. (2011) Dopaminergic modulation of risky decision-making. Journal of Neuroscience, 31, 17460-17470.
doi:10.1523/JNEUROSCI.3772-11.2011
has been cited by the following article:
-
TITLE:
Variation in the DRD2 gene affects impulsivity in intertemporal choice
AUTHORS:
Yoshiya Kawamura, Taiki Takahashi, Xiaoxi Liu, Nao Nishida, Yoshihiro Noda, Akane Yoshikawa, Tadashi Umekage, Tsukasa Sasaki
KEYWORDS:
Dopamine receptor D2 (DRD2); Impulsivity; Neuroeconomics; Single Nucleotide Polymorphism (SNP); Time-Discount Rate
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.3 No.1,
January
29,
2013
ABSTRACT:
Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dopaminergic systems. Dopamine receptor D2 (DRD2) is the D2 subtype of the dopamine receptor of the G-protein coupled receptor family. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) in DRD2 gene on delay discounting. Methods: The participants consisted of 91 healthy Japanese people (66 males and 25 females with a mean age of 40.9 ± 6.9 years). Each participant completed the Kirby’s monetary choice questionnaire (MCQ) for delayed gain and donated a whole blood sample. Two SNPs (C957T (rs6277) and TaqI A (rs1800497)) in DRD2 were genotyped by using the DigiTag2 assay. SNP linear regression analyses with 100,000 permutations were conducted for the hyperbolic time-discount rate (k). Results: The SNP C957T showed a significant association; participants with more minor alleles (T) were more impulsive in intertemporal choice for delayed gain (multiplicity-corrected P = 0.041 with a small effect size). Conclusion: The variation in the DRD2 gene is associated with impulsive decision-making. This is the first study to demonstrate an association between DRD2 and impulsivity in intertemporal choice with a multiplicity-corrected significance.
Related Articles:
-
Niki C. Kuin, Erik J. A. Scherder, Hanneke Gijsbers, Erik D. M. Masthoff
-
Ann-Kathrin Emser, Simon Heintzen, Claas Beeser, Barbara Stoberock, Nicki Marquardt
-
Peter Walla
-
Chao Fu
-
François P. R. de Villiers