TITLE:
Reduced endogenous insulin secretion in diabetic patients with low-titer positive antibodies against GAD
AUTHORS:
Yuichiro Takeuchi, Hiroyuki Ito, Koshiro Oshikiri, Shinichi Antoku, Mariko Abe, Mizuo Mifune, Michiko Togane, Masahiro Kato
KEYWORDS:
GAD Antibody; Endogenous Insulin Secretion; Urinary C-Peptide; SPIDDM; LADA
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.2 No.1,
February
22,
2012
ABSTRACT: Aim: To investigate the clinical characteristics of diabetic patients with a low-titer positive for the anti-glutamic acid decarboxylase 65 antibody (GAD antibody). Methods: The subjects were 420 diabetic inpatients. The endogenous insulin secretion was estimated on the basis of the C-peptide immunoreactivity from a 24 h urine collection (uCPR). Clinical variables were compared between patients negative for the GAD antibody (GAD antibody titer