TITLE:
The role of diabetes mellitus in localized and metastatic renal cell carcinoma
AUTHORS:
Sandra Steffens, Christoph von Klot, Hendrik Egggers, Christoph Seidel, Gerd Wegener, Mark Schrader, Markus A. Kuczyk, Andres J. Schrader
KEYWORDS:
Renal Cell Cancer; Risk Factor; Diabetes Mellitus; Survival; Prognosis
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.1 No.4,
November
8,
2011
ABSTRACT: Introduction & Objectives: Until recently, the incidence of renal cell carcinoma (RCC) has been increasing worldwide, mainly in western countries, at a rate between 2% and 4% per year. However, the reason for this dramatic increase in number has not been fully understood. Diabetes mellitus (DM) is a known risk factor for RCC, but the impact of DM on the prognosis of RCC is unclear. In the present study, we investigated the potential influence of DM on clinicopathological features of localized and metastatic RCC. Material & Methods: We evaluated 863 patients with primary RCC who had undergone renal surgery between 1991 and 2005 in the University Hospital Hannover; the mean follow-up was 58 months. To test the association of DM with survival end-points, Kaplan-Meier Method and Cox multivariable logistic regression models were applied. Results: In total, we identified 123 diabetic patients who suffered from RCC, 9 patients with diabetes type 1 and 114 with type 2. Patients with DM type 2 presented significantly more often with pT1a tumours at diagnosis (40.0 vs. 31.7%, p = 0.02), had less frequently high grade cancer (G3/4; 10.3 vs. 16.2%, p = 0.03), were older (median, 65.3 vs. 61.6 years; p