TITLE:
Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo
AUTHORS:
Maindo Alongo Mike-Antoine, Juakali Sihalikyolo, Salomon Batina Agasa, Antoine Modia O’yandjo, Bernard Mbutu, Gédéon Katenga Bosunga, Jean-Pascal Manga Okenge
KEYWORDS:
Antisperm Antibody, Chlamydia Trachomatis, Men Infertility, Immune Infertility, Infertility, Democratic Republic of Congo
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.8,
August
9,
2019
ABSTRACT: Introduction: Antisperm antibodies (ASA) prevalence is high in Kisangani. ASA are one
of the male factors of infertility that can reduce spermatozoa motility and
cervical penetration or prevent acrosomal reaction and even alter embryo
development. This study aims to
determine the risk factors of ASA positivity among infertile men in Kisangani. Patient
and Method: We conducted a case-control study during a period of 2 years in
Kisangani on 111 men who consulted for conception and tested for ASA by ELISA.
We did a simple pairing that concerned only the type of infertility. For a
better balance between the number of cases and controls per stratum to provide
better accuracy in the adjusted OR estimate, we performed a 1:1 match. Results: This study showed that businessmen [ORa = 5.0000(1.2452 - 20.0767)] and jobless
[ORa = 5.8125(1.1477 - 29.4367)] were at risk of being positive for ASA. Violent
blow to testicles [ORa = 6.7391(1.3455 - 33.7545)], cure of hernia [ORa =
4.3478(1.0722 - 17.6299)], Chlamydia infection [ORa = 4.7125(1.3405 - 16.5665)],
leucospermia [ORa = 4.1429(1.0406 - 19.7155)] and
presence of Staphylococcus aureus [ORa = 3.4444(0.6410 - 18.5082)] were
associated to positive ASA. Conclusion: This study shows that factors
that may lead to risky sexual behavior and physical or infectious trauma are
important risk factors for ASA positivity. It is therefore necessary to search
for them systematically during male infertility in order to guide the search
for ASA.