Dimpfel, W., Todorova, A. and Vonderheid-Guth, B. (1999) Pharmacodynamic Properties of St. John’s Wort—A Single Blind Neurophysiological Study in Healthy Subjects Comparing Two Commercial Preparations. European Journal of Medical Reserach, 4, 303-312.

has been cited by the following article:

• TITLE: Effects of Neurexan on Stress-Induced Changes of Spectral EEG Power: A Double-Blind, Randomized, Placebo-Controlled, Crossover Exploratory Trial in Human Volunteers

  AUTHORS: Wilfried Dimpfel

  KEYWORDS: Stress, Anxiety, qEEG, Brain Map, Brainwave Frequency, Homeopathy, Neurexan, Nx4

  JOURNAL NAME: World Journal of Neuroscience, Vol.9 No.3, July 25, 2019

  ABSTRACT: Neurexan is a multicomponent natural medicinal productusedforstress-relatedsymptoms such as nervous restlessness and insomnia. The present studyinvestigatedtheefficacyof Neurexan on stress-induced changes of brainwave frequenciesusing quantitative analysis of spectral EEG power. Thirty healthy male and female volunteers were tested in a randomized, placebo controlled cross-over trial under conditions of relaxation and experimental stress-in-duction. Recording of the EEG was performed over four hours after drug administration. Data wasanalyzed using the proprietary fast dynamic EEG technology Neurocode-Tracking. Quantitative EEG revealed a task dependent increase of beta2 power as a surrogate parameter of stress induced anxiety. The elevated frontotemporal beta2 power was ameliorated by intake of Neurexan during the second and third hour after administration. This indicates that Neurexan is effectively helping subjects to better cope with task-related stress situations.