TITLE:
Progress toward the Synthesis of Pochonin J
AUTHORS:
Sydney N. Jackson, Rongson Pongdee
KEYWORDS:
Natural Products, Pochonin J, Resorcylic Acid Lactones
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.9 No.2,
June
13,
2019
ABSTRACT: The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans’ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.