Topcu, Y., Bavram, E., Karaoglu, P., Yis, U. and Kurul, S.H. (2013) The Combination of Thermal Dysregulation and Agenesis of Corpus Callosum: Shapiro’s or/and Reverse Shapiro’s Syndrome. Annals of Indian Academy of Neurology, 16, 716-719.
https://doi.org/10.4103/0972-2327.120451

has been cited by the following article:

• TITLE: Hyperhidrosis of Central Hypogonadism Leading to Diagnosis of Shapiro Syndrome: Temperature Dysregulation, Hypothermia and Agenesis of the Corpus Callosum

  AUTHORS: Megan A. Traxinger, Emily A. Beckett, Dana Danley, Udaya M. Kabadi

  KEYWORDS: Hyperhidrosis, Central Hypogonadism, Temperature Dysregulation, Callosal Agenesis, Shapiro Syndrome

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.9 No.1, January 29, 2019

  ABSTRACT: Background: Central or hypothalamic hypogonadism as an initial manifestation of Shapiro Syndrome has not been described in the literature. Herein, we report first case in which initial presentation of central hypogonadism led to a confirmed diagnosis of Shapiro Syndrome during a casual evaluation of hypothalamic pituitary anatomy with MRI of brain. Case presentation: 53 year old Caucasian man was documented to manifest Central or hypogonadotropic hypogonadism following evaluation of excessive sweating episodes, lack of libido and erectile dysfunction for a duration of several years. Brain MRI performed for assessment of the etiology documented no pituitary abnormality. Instead agenesis of Corpus Callosum was noted. The subject had been hospitalized on many occasions at this and several other medical centers with hypothermia or hyperthermia without a documentation of a definite cause. Therefore, the diagnosis of Shapiro Syndrome was made. Conclusion: This report is the first documentation of subject manifesting central, more likely to be hypothalamic rather than hypogonadotropic hypogonadism in conjunction with Shapiro Syndrome.