TITLE:
Effect of Insulin Glargine on Cardiovascular Risk Analysed by Mean HRV
AUTHORS:
Marchitto Nicola, Marcinnò Mariaconcetta, Petrucci Alessia, Apicella Giovanni, Dal Maso Serenella Gioia, Raimondi Gianfranco
KEYWORDS:
Insulin Glargine, Diabetes, HRV, Cardiovascular Risk, Geriatry
JOURNAL NAME:
Health,
Vol.11 No.1,
January
11,
2019
ABSTRACT: Type 2 diabetes mellitus is an insidious disease that is increasingly present in geriatric population [1]. The greatest difficulty is represented by glycaemic control in geriatric patients often not very compliant with diet therapy and drug therapy. A new insulin glargine 300 units/ml formulation seems improve patient compliance due to the lower volume of insulin to be injected and improved glycaemic control over 24 hours. The HRV signal, derived from digital electrocardiographic recording, is the simplest and most immediate analysis that consists in calculating some temporal parameters [2]. HRV is a simple statistics derived from beat-beat intervals of sinus origin expressed as units of time in milliseconds. Data in the literature indicate that a decrease in HRV, measured with time domain analysis, denotes a worse prognosis and/or an increased risk of mortality in patients with heart disease, especially in the elderly ones.