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https://doi.org/10.1371/journal.pgen.1001374

has been cited by the following article:

• TITLE: Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-κB Signalling in Cattle Health

  AUTHORS: Xing Chen, Shujun Zhang, Zhangrui Cheng, Geoffrey E. Pollott, D. Claire Wathes

  KEYWORDS: Mastitis, Longevity, RelA, NF-κB, Dairy Cow

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.9 No.1, January 4, 2019

  ABSTRACT: Mastitis reduces milk production and causes culling. The NF-κB transcription factor RelA plays a central regulatory role in innate immunity. This study used a candidate gene approach to investigate associations between the synonymous C/G SNP rs48035703 in RELA with somatic cell count (SCC) and survival time. Blood samples were collected from 337 Holstein-Friesian heifers on 19 farms and genotyped by PCR-restriction fragment length polymorphism. Animals were monitored from 6 months until 2340 d of age. Pedigree, milk production and disease records were obtained. Genotype frequencies were CC 0.63, CG 0.30 and GG 0.06. The C allele had a favourable additive effect on survival: average longevities from birth were CC, 1872 d; CG, 1745 d and GG 1596 d (P -0.04 ± 0.803, P RELA rs48035703 CC genotype cows were therefore less likely to experience a high SCC and survived longer. These results support a role for RelA in combating mammary gland infection and warrant further studies in additional populations.