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https://doi.org/10.1016/S1090-0233(05)80007-3
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TITLE:
Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-κB Signalling in Cattle Health
AUTHORS:
Xing Chen, Shujun Zhang, Zhangrui Cheng, Geoffrey E. Pollott, D. Claire Wathes
KEYWORDS:
Mastitis, Longevity, RelA, NF-κB, Dairy Cow
JOURNAL NAME:
Open Journal of Animal Sciences,
Vol.9 No.1,
January
4,
2019
ABSTRACT: Mastitis reduces milk
production and causes culling. The NF-κB transcription factor RelA plays a
central regulatory role in innate immunity. This study used a candidate gene
approach to investigate associations between the synonymous C/G SNP rs48035703
in RELA with somatic cell count (SCC)
and survival time. Blood samples were collected from 337 Holstein-Friesian
heifers on 19 farms and genotyped by PCR-restriction fragment length polymorphism.
Animals were monitored from 6 months until 2340 d of age. Pedigree, milk
production and disease records were obtained. Genotype frequencies were CC
0.63, CG 0.30 and GG 0.06. The C allele had a favourable additive effect on
survival: average longevities from birth were CC, 1872 d; CG, 1745 d and GG
1596 d (P -0.04 ± 0.803, P RELA rs48035703 CC genotype cows were therefore less likely to experience a high
SCC and survived longer. These results support a role for RelA in combating
mammary gland infection and warrant further studies in additional populations.
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Luciana G. Brito, José R. Vieira Júnior, Fábio da S. Barbieri, Rodrigo B. Rocha, Marivaldo R. Figueiró, Websten C. da Silva, Gilvânia L. O. Carvalho, Guilherme N. Souza, José de Arimatéia Silva
DOI:
10.4236/ojvm.2016.69018
1,296 Downloads 1,793 Views Citations
Pub. Date:
September
27,
2016
