TITLE:
Histochemical Patterns of Collagenic Fibers in the Benign and Malignant Breast Lesions
AUTHORS:
Abdulbaset Mohamed Elasbali
KEYWORDS:
Cancer, Collagen, Malignant Lesions, Benign Tumor
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.8 No.1,
December
14,
2018
ABSTRACT: Cancer
is one of the leading causes of death worldwide and breast cancer is the most commonly diagnosed
cancer among women. An increased incidence of different types of breast cancer
has been reported. This study was designed to evaluate the different types of
breast cancer and its possible risk of neoplasmic transformation to an advanced
malignant stage from a benign tumor. The histochemical patterns of collagen
fibers in the benign and malignant breast lesions were evaluated. From the 50
tissue samples, 25
were malignant breast lesions and 25 were benign breast tumor. Hematoxylin and
Eosin (HE), Van Gieson staining
were performed to detect a benign and malignant tumor as well as collagen
fibers. We found that significant cases after age of 35 were associated with ductal
carcinoma while most of the cases within the age of 25 years were associated
with fibrocystic changes. The intensity of collagen fiber was higher to Ductal
Carcinoma while negative and less intense for Fibroblastic changes.
Furthermore, a consistent association of other lesions, such as Lobular Carcinoma, Fibroadenoma, Papilloma
and Fat necrosis and noticeable staining for collagen was observed for the
different lesion. Our study suggested that women with age of 25 with benign
lesion of fibrocystic change and ductal carcinoma are highly susceptible to
develop advanced malignant tumor with age. Therefore, quantitative measurement
of collagen fiber and regular follow-up are recommended to avoid the possible risk of developing advanced
malignant lesions.