TITLE:
Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats
AUTHORS:
Galina Sukoyan, Edisher Tsivtsivadze, Veronika Golovach, Tamara Kezeli, Natalya Demina
KEYWORDS:
Skin, Aging, Collagen, Pure Water Cynara cardunculus L. var. Cynara scolymus L. Extract, Nuclear Transcription Factor Kappa B
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.9 No.10,
October
26,
2018
ABSTRACT: The aim of the study was to evaluate the efficacy of
2% Cynara scolymus L. extracts in reverse disturbances of collagen
metabolism and inflammation in D-galactose induced skin aging model in rats.
D-galactose induced aging reproduced in 48 animals of main group, and 12 rats
in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic
acid 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4
weeks. Influence of artichoke extracts restored skin relative weight and led to
an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the
hexosamine/collagen (hydroxyproline) ratio and decreased the activity of
nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke
extracts improved collagen metabolism and attenuated the progression of
inflammation in D-galactose induced skin aging model.