TITLE:
Management of Pregnant Women with Invasive Cervical Cancer about Ten Cases
AUTHORS:
K. Diabaté, H. Bakkali, A. Lachgar, S. Nadir, T. Kebdani, B. K. El Gueddari, N. Benjaafar
KEYWORDS:
Cervical Cancer, Pregnancy, Treatment
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.9,
September
19,
2018
ABSTRACT: The purpose of this study was to update the management of invasive
cervical cancers diagnosed during pregnancy. Patients and methods: This study
was performed retrospectively at radiotherapy department of National Institute
of Oncology Rabat Morocco. From 01/04/2005 to 31/05/2010, ten
patients with invasive cervical cancer during pregnancy were included. Results:
Ten patients were included in the study. The staging was as follow: stage IIIB
(n = 4); stage IIB (n = 2) and stage IB2 (n = 4). The radical abdominal
hysterectomy with pelvic lymphadenectomy was performed in five patients; a
therapeutic interruption of pregnancy was performed in four patients. One
pregnancy has resulted in the birth of a living child (by cesarean section).
Adjuvant treatment was concomitant chemoradiotherapy followed by low dose rate
(LDR) brachytherapy in three patients; adjuvant concomitant chemoradiotherapy
followed by high dose rate (HDR) brachytherapy was performed in four patients; a HDR brachytherapy was done in one patient. Two
patients have received an exclusive external radiotherapy. After a median
follow-up of 4 years (2 - 7 years), there were bone and lung metastases in
one patient. Nine patients are alive after completed treatment. Conclusion: Our
series focused on ten patients with invasive cervical cancer during pregnancy.
Management is complex and requires discussion in a multidisciplinary meeting.
Routine screening of cervical cancer and awareness are the key point to improve
the treatment and survival rate of patients. The management of all cases is according to international recommendations.