TITLE:
Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat
AUTHORS:
Takeshi Ohta, Tomohiko Sasase, Takayuki Gotoh, Masami Shinohara, Phanthila Sirichaiyakul, Suhattaya Furuta, Rumpar Techasakulsin, Taiichiro Kamiya, Chikako Yoshida, Takahisa Yamada
KEYWORDS:
Diabetic Model, GK Rat, SDT Rat, Type 2 Diabetes
JOURNAL NAME:
Open Journal of Animal Sciences,
Vol.8 No.4,
September
13,
2018
ABSTRACT: The number of diabetic patients has recently been
increasing all over the world together with lifestyle changes including
sedentary life and high-calorie diet intake, and as a result the increase in
these suffering from diabetes mellitus has become a global issue. Diabetic
animal models play a key role in bettering our understanding of the pathophysiology
of diabetes and in developing new therapies for the disease. Diabetes is
classified into two types, type 1 and type 2, and type 2 diabetes is chiefly
caused by a depletion of insulin secretion in the pancreas and insulin
resistance in peripheral tissues. The Goto-Kakizaki (GK) rat and the
Spontaneously Diabetic Torii (SDT) rat are genetic non-obese type 2 diabetic
models, and the both rats are considered to be suitable models for
investigating the etiology of the depletion of insulin secretion and impaired
glucose tolerance. In this review, we overviewed the outline of
pathophysiological features in GK rats and SDT rats, including biological
parameters and pharmacological responses.