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has been cited by the following article:

• TITLE: Catechol-O-Methyl Transferase (COMT) Enzyme Gene Variations in Patients with Idiopathic Scoliosis: A Clinical Chart Review

  AUTHORS: Mark W. Morningstar, Megan N. Strauchman, Clayton J. Stitzel, Brian Dovorany, Aatif Siddiqui

  KEYWORDS: Enzyme, Genetics, Genomics, Neurotransmitters, Scoliosis

  JOURNAL NAME: Open Journal of Genetics, Vol.8 No.3, July 13, 2018

  ABSTRACT: The effects of genomic variations and their associations with idiopathic scoliosis have been the discussion of many research trials. Previous investigations into catechol-o-methyl transferase (COMT) have identified its importance in dopamine and estrogen metabolism. While many genetic influences on idiopathic scoliosis have been observed, there has been no report of any relationship between COMT mutations and idiopathic scoliosis. The present study compared two groups of patients who received COMT genetic testing. The first group had a history of idiopathic scoliosis, while the other served as a non-scoliotic control group. The scoliosis group showed a positive COMT mutation in 33 out of 58 patients, while the control group showed 22/58 (P